Variability of “Reported Fetal Fraction” in Noninvasive Prenatal Screening (NIPS)
نویسندگان
چکیده
منابع مشابه
MeDIP Real-Time qPCR has the Potential for Noninvasive Prenatal Screening of Fetal Trisomy 21
This study aimed to verify the reliability of the 7 tissue differentially methylated regions used in the methylated DNA immunoprecipitation (MeDIP) real-time quantitative polymerase chain reaction (real-time qPCR) based approach of fetal DNA in maternal blood to diagnosis of fetal trisomy 21. Forty pregnant women with high risk pregnancy who were referred after first or second trimester screeni...
متن کاملResponse to “Noninvasive prenatal screening at low fetal fraction: comparing whole‐genome sequencing and single‐nucleotide polymorphism methods”
This correspondence addresses the issues raised by Ryan and Martin in an accompanying letter to the editor regarding our published manuscript entitled “Noninvasive Prenatal Screening [NIPS] at Low Fetal Fraction: Comparing WholeGenome Sequencing and Single-Nucleotide Polymorphism Methods”. The aim of our study was to compare the performance and clinical consequences of the two main methods of N...
متن کاملComment on “Noninvasive prenatal screening at low fetal fraction: comparing whole‐genome sequencing and single‐nucleotide polymorphism methods”
This correspondence is in reference to the article entitled, ‘Noninvasive Prenatal Screening at Low Fetal Fraction: Comparing Whole-Genome Sequencing and Single-Nucleotide Polymorphism Methods’ by Artieri, et al., which was recently published in Prenatal Diagnosis. The objective of the publication was to compare the performance of two non-invasive prenatal testing (NIPT) methods, whole-genome s...
متن کاملBioinformatics Approaches for Fetal DNA Fraction Estimation in Noninvasive Prenatal Testing
The discovery of cell-free fetal DNA molecules in plasma of pregnant women has created a paradigm shift in noninvasive prenatal testing (NIPT). Circulating cell-free DNA in maternal plasma has been increasingly recognized as an important proxy to detect fetal abnormalities in a noninvasive manner. A variety of approaches for NIPT using next-generation sequencing have been developed, which have ...
متن کاملP-226: Non-Invasive Prenatal Screening for Fetal Chromosomal Anomalies in South of Iran
Background: Prenatal diagnosis for Fetal Chromosomal anomalies currently relies on assessment of risk followed by a combination of biochemical and nuchal translucency. Trisomy 21 is the most common trisomy that is associated with intellectual disability. Pregnant women who receive a prenatal diagnosis of trisomy 21 currently have the option of continuing or terminating their pregnancy, but no f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2021
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/hvab014